Hemophilia A

What is Hemophilia A?

Hemophilia A is the most common type of hemophilia and is caused by deficient or dysfunctional clotting factor VIII. Although hemophilia A is usually inherited, about 30% of cases are caused by a spontaneous mutation in the person’s own genes. 

Hemophilia A affects about 1 in 12,000 people and is diagnosed by taking a blood sample and measuring the level of factor activity in the blood. Hemophilia A is diagnosed by testing the level of factor VIII activity in the blood. 

Hemophilia A can be mild, moderate, or severe, depending on how much clotting factor is in an affected person's blood. However, about 60% of patients have the severe form of the disorder. People with hemophilia A have prolonged bleeding after an injury, surgery, or tooth extraction. In severe cases, they may bleed once or twice a week and often the bleeding is spontaneous, which means it happens for no obvious reason. Serious complications can result from bleeding into the joints, muscles, brain, or other internal organs. In a mild case of hemophilia A, the disorder may remain unknown until after a surgery or serious injury.

Treatment for hemophilia A is very effective and with appropriate treatment and care, people with hemophilia A can live perfectly healthy lives. The main treatment is called replacement therapy, during which clotting factor VIII is infused into a vein either prophylactically (preventatively) or on-demand to prevent or treat bleeds.

Hemophilia A patient Tim Grams

Living with Severe Hemophilia

What do patients want people to understand about this rare disease?

Watch one patient's tips

Here is a sampling of our Vita stories on Hemophilia:

To read all of our stories, please visit our Vita homepage.

Cartoon parents holding a baby
What is hemophilia?

The inherited bleeding disorder is explained in CSL Behring's original animation.

Cody driving an ambulance.
A family bond built through hemophilia

Brothers with the rare disease help others undergoing a medical emergency.

Hemophilia Doctor Measuring Patients Blood Pressure
Hemophilia and hypertension: A curious connection

People living with hemophilia are more likely to develop hypertension at a younger age.

Resources for you

AFSTYLA Facebook Page Provides Hemophilia A patients and their families with information on AFSTYLA, patient stories and support programs. View Website  
Signs of Bleeding The 5 signs of a bleeding disorder View Website
World Federation of Hemophilia A global organization aiming to improve and sustain care for people with inherited bleeding disorders.
View Website
National Hemophilia Foundation A U.S. organization dedicated to finding better treatments and cures for inheritable bleeding disorders.
View Website
Hemophilia Federation of America A U.S. a national nonprofit organization that assists and advocates for the bleeding disorders community.
View Website
Product Websites AFSTYLA.com (United States)
Humate-P.com (United States)
HelixateFS.com (United States)
Beriate.de (Germany)

Treatments Available

Availability of treatments may vary from country to country. Please be sure to visit your local CSLBehring.com site for further information.

AFSTYLA® Antihemophilic Factor (Recombinant), Single Chain Visit Website pdf
Humate-P® / Haemate® P Antihemophilic Factor/von Willebrand Factor Complex (Human) Visit Website pdf
(Desmopressin acetate) Nasal Spray, 1.5 mg/mL   pdf
Helixate®FS / Helixate® NexGen
 Antihemophilic Factor (Recombinant) Formulated with Sucrose Visit Website pdf
Antihemophilic Factor (Human) Factor VIII:C Pasteurized Monoclonal Antibody Purified   pdf
Beriate®   Visit Website  

Current Clinical Trials

Please see below for any current clinical trials for this condition.

Condition Description
 Hemophilia A An Open-label Safety and Efficacy Study of Recombinant FVIII in Patients With Severe Hemophilia A. Learn More
Looking down into microscope and taking notes

Participate in Clinical Trials

Discover what is involved in participating in one of our clinical trials and how you can enroll.

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