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Factor XIII Deficiency

What is a Factor XIII deficiency?

Factor XIII deficiency is a rare inherited bleeding disorder in which Factor XIII, the protein in the blood responsible to help stabilize a blood clot, is malfunctioning or deficient. If you are deficient in Factor XIII, your body is able to form blood clots, but they often are weak and therefore break down, resulting in prolonged bleeding.

According to the National Organization of Rare Disorders (NORD), the incidence of Factor XIII deficiency has been estimated to be between 1 in 2-5 million people in the general population. Common symptoms of Factor XIII deficiency include soft-tissue bleeds, intracranial bleeding, menorrhagia (heavy menstrual bleeding) and joint bleeding.

Resources for you

Resource Description  
World Federation of Hemophilia A global organization aiming to improve and sustain care for people with inherited bleeding disorders. View Website
National Hemophilia Foundation A U.S. organization dedicated to finding better treatments and cures for inheritable bleeding disorders. View Website
Hemophilia Federation of America A U.S. nonprofit organization that assists and advocates for the bleeding disorders community. View Website

Treatments Available

Availability of treatments may vary from country to country. Please be sure to visit your local site for further information.

 Corifact® | FXIII Concentrate (Human)

US Prescribing Information

US Important Safety Information(Selected) 

Do not use Corifact if you have experienced severe, immediate sensitivity reactions (including shock) to human plasma-derived products. Contact your physician, treatment administrator or local emergency department right away if you notice any of the following symptoms after using Corifact: shortness of breath, hives, rash, chest pain or tightness, wheezing, fainting or dizziness, or any sign of a blood clot. These are not the only possible symptoms; tell your doctor about any symptom that bothers you or does not go away.

Full US Important Safety Information

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