Understanding Hereditary Angioedema
HAE is a rare hereditary disease that can cause attacks of swelling, and often pain, in specific parts of the body including the stomach, hands, feet, arms, legs, genitals, throat, and face. Depending on the severity of the disease, some people will have many attacks each month, while others will go months without an attack.
People with HAE are missing or have low levels of a protein called C1 esterase inhibitor (C1-INH); in some cases, the C1-INH levels are sufficient but the protein does not function properly. The defect with C1-INH lies within a person's genetic code, which is why HAE runs in families.
HAE is classified into 3 types based on what problem the genetic defect causes. A person can have low levels of C1-INH in the body (type I HAE), poorly functioning C1-INH (type II HAE), or HAE with normal functioning C1-INH (formerly known as type III HAE). The last type is not well understood.
It's the Little Things
HAE patient Machelle Pecoraro faced a long, difficult journey to diagnosis. One of the lessons she learned during that journey was to take time out to appreciate the little things.
1 / 40,000 - 50,000
people affected with HAE
chance of someone with HAE passing it on to a child
200 different genetic mutations causing symptoms of HAE have been identified to date
Resources for you
Availability of treatments may vary from country to country. Please be sure to visit your local CSLBehring.com site for further information.