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Perioperative Bleeding - Massive Bleeding

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Coagulation abnormalities can arise from massive bleeding, such as loss, consumption or dilution of coagulation factors, platelets and other blood cells involved in hemostasis. 4
Massive bleeding is commonly defined as loss of entire blood volume within 24 hours, or loss of 50% of blood volume within three hours. 14

Massive bleeding and coagulopathy may be associated with a number of conditions and procedures such as advanced liver disease, obstetric complications (post-partum hemorrhage), disseminated intravascular coagulation (DIC), major trauma or surgery. It may also be caused by a deficiency in plasma fibrinogen levels. 4-5

CSL Behring products used in the treatment of coagulopathy associated with massive bleeding include:

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