von Willebrand Disease
What is von Willebrand Disease?
The most common bleeding disorder is von Willebrand disease (VWD) which affects 1% of the world’s population. VWD is typically an inherited disease and caused by deficient or defective von Willebrand Factor (VWF). It occurs in both men and women and is diagnosed by measuring the level and activity of VWF and factor VIII.
There are three main types of von Willebrand disease. Type I is most common and the mildest, and type 3 the rarest and most severe form. Type 3 is usually inherited in an autosomal recessive manner in which the child receives defective gene from both parents. People with type 3 condition have very little or no VWF and experience spontaneous bleeding episodes often into joints and muscles. People with VWD experience prolonged bleeding after injury, surgery, dental work or childbirth. Women with VWD have heavy or prolonged menstrual bleeding.
The treatment depends on the type and severity of VWD. Type 3 patients and patients at risk of severe bleeding in type I and type 2 are often treated with factor concentrates that contain FVIII and are rich in VWF.
Outdoor and music enthusiast Roberta Smith can trace her family history with von Willebrand Disease (VWD) back to her paternal great-grandfather. Despite a lifetime of challenges living with the genetic disease, Roberta lives life to the fullest with her husband and family.
Read our Vita stories on VWD
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Resources for you
Availability of treatments may vary from country to country. Please be sure to visit your local CSLBehring.com site for further information.
Current Clinical Trials
Please see below for any current clinical trials for this condition.