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von Willebrand Disease

What is von Willebrand Disease?

The most common bleeding disorder is von Willebrand disease (VWD) which affects 1% of the world’s population. VWD is typically an inherited disease and caused by deficient or defective von Willebrand Factor (VWF). It occurs in both men and women and is diagnosed by measuring the level and activity of VWF and factor VIII.

VWD occurs when von Willebrand factor (VWF), a protein that helps form blood clots to stop bleeding, is missing or doesn’t work the way it should. Because of this, when people with VWD bleed from cuts or injuries, their bleeding takes longer to stop.

There are three main types of von Willebrand disease. Type 1 is most common and the mildest, and type 3 the rarest and most severe form. Type 3 is usually inherited in an autosomal recessive manner in which the child receives defective gene from both parents. People with type 3 condition have very little or no VWF and experience spontaneous bleeding episodes often into joints and muscles. People with VWD experience prolonged bleeding after injury, surgery, dental work or childbirth. Women with VWD have heavy or prolonged menstrual bleeding.

The treatment depends on the type and severity of VWD. Type 3 patients and patients at risk of severe bleeding in type 1 and type 2 are often treated with factor concentrates that contain FVIII and are rich in VWF.

Von Willebrand disease patient Kim Walsh

Living Your Life with von Willebrand Disease

Kim Walsh has VWD. Her number one tip: Don't let it limit your life.

Watch Kim's tips

Resources for you

Resource Description  
World Federation of Hemophilia A global organization aiming to improve and sustain care for people with inherited bleeding disorders. View Website
National Hemophilia Foundation A U.S. organization dedicated to finding better treatments and cures for inheritable bleeding disorders. View Website
Hemophilia Federation of America A U.S. nonprofit organization that assists and advocates for the bleeding disorders community. View Website

Treatments Available

Availability of treatments may vary from country to country. Please be sure to visit your local site for further information.

 Humate-P® | Antihemophilic Factor/von Willebrand Factor Complex (Human)
 Known outside the US as: Haemate® P 

US Prescribing Information

US Important Safety Information(Selected) 

Do not take Humate-P if you have had extreme sensitivity or an allergic response to antihemophilic or von Willebrand factor preparations. Your doctor will monitor you for events related to abnormal blood clotting.

In studies, more than 5% of patients reported the following adverse reactions to Humate-P: allergic/anaphylactic reactions, including hives, chest tightness, rash, itching, and swelling. The most common adverse reactions after surgery were bleeding at the wound or infusion site, and nosebleeds.

Full US Important Safety Information

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