Virus elimination or virus filtration (nanofiltration) removes viruses by size exclusion. In particular, filters with a defined small pore size remove viruses with a diameter larger than the pore size. The main advantage of this process is that both enveloped and non-enveloped viruses can be removed without denaturing plasma proteins and affecting the quality of the derived products.

Virus filtration (nanofiltration) physically removes viruses

CSL Behring was the first biopharmaceutical company to develop and utilize nanofiltration in our Bern, Switzerland facility. During our process, protein solutions are filtered through membranes with very small pore sizes (typically 15-40 nm).

Nanofiltration eliminates viruses:

Nanfiltration eliminates viruses