A1-PI deficiency is a hereditary disorder that can result in emphysema -- a chronic, obstructive lung disease. If left untreated, emphysema can lead to severe tissue damage and death.
A1-PIs inhibit lung tissue degradation and are indicated as maintenance therapy for patients with A1-PI deficiency with clinical evidence of emphysema.
Human alpha1-proteinase inhibitor is indicated for maintenance therapy for patients with A1-PI deficiency and clinical evidence of emphysema.