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Von Willebrand Disease (VWD)

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Von Willebrand Disease (VWD) is a bleeding disorder caused by genetic defects in chromosome 12. These defects cause a deficiency in the quality or quantity of a protein known as von Willebrand Factor (VWF). VWF plays an essential role in the first stage of coagulation. 1-2

VWD is the most common inherited bleeding disorder. It is usually mild and does not generally cause spontaneous bleeding. 3

There are three main types of VWD: 4 

Type 1
Characterized by decreased levels of VWF and sometimes factor VIII, type 1 is the mildest and most common form of VWD, accounting for around 75% of all cases of VWD.
Type 2
VWF does not function properly in type 2 VWD. Type 2 is further divided into subtypes, as a result of different gene mutations: 2A, 2B, 2M and 2N.
Type 3
Characterized by an absence of VWF and decreased levels of factor VIII, type 3 is the most severe form of VWD, but it is very rare.

CSL Behring products used in the treatment of von Willebrand disease include: 

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